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Bruce Fischl, Ph.D.

Associate Professor,  Radiology, Harvard Medical School
Director, Computational Core, Athinoula A Martinos Center, Department of Radiology, Massachusetts General Hospital
Research Scientist, Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology

B.A. – Wesleyan University, 1985
Ph.D. – Boston University, 1996

Dr. Fischl's current research focuses on the development of techniques for the automatic construction and utilization of geometrically accurate and topologically correct models of the human cerebral cortex. These models are based on high-resolution T1-weighted MR images, and their primary utility has been as a domain for the visualization of cortical neuroimaging data. They have also been useful as a substrate for combining neuroimaging data from different imaging modalities in order to obtain high spatial and temporal resolution. In addition, Dr. Fischl has developed a technique that exploits the correlation between cortical folding patterns and cortical function in order to generate a more accurate mapping across different brains for inter-subject averaging, Another focus of Dr. Fischl’s research has been increasing the accuracy of the models ofgray/white surface as well as the pial surface itself. The combination of these two surfaces allows one to measure the thickness of the gray matter of the cortex. The thickness of the cortical ribbon is of great clinical and research significance as many neurodegenerative diseases result in progressive, regionally specific atrophy of the cortical gray matter.

Recent Publications:

  1. Fischl B, Cohen M, Schwartz E. The local structure of space-variant images. Neural Networks 1997; 10: 815-831.
  2. Fischl B, Schwartz E. Learning an integral equation approximation to nonlinear anisotropic diffusion in image processing. IEEE PAMI 1997; 19: 342-352.
  3. Fischl B, Cohen M, Schwartz E. Rapid anisotropic diffusion using space-variant vision. IJCV 1998; 28: 199-212.
  4. Dale A, Fischl B, Sereno M. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999; 9: 179-194.
  5. Fischl B, Sereno M, Dale A. Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999; 9: 195-207.
  6. Fischl B, Sereno M, Tootell R, Dale A. High-resolution intersubject averaging and a coordinate system for the cortical surface. Human Brain Mapping 1999; 8: 272-284.
  7. Mendola J, Dale A, Fischl B, Liu A, Tootell R. The representation of illusory and real contours in human cortical visual areas revealed by functional magnetic resonance imaging. J Neurosci 1999; 19: 8560-8572.
  8. Fischl B, Schwartz E. Adaptive nonlocal filtering: A fast alternative to anisotropic diffusion for image enhancement. IEEE PAMI 1999; 21: 42-49.
  9. Fischl B, Dale A. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 2000; 97: 11050-11055.
  10. Dale AM, Liu AK, Fischl BR, Buckner RL, Belliveau JW, Lewine JD, Halgren E. Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity. Neuron 2000; 26: 55-67.
  11. Moore CI, Stern CE, Corkin S, Fischl B, Gray AC, Rosen BR, Dale AM. Segregation of somatosensory activation in the human rolandic cortex using fMRI. J Neurophysiol 2000; 84: 558-569.
  12. Fischl B, Liu A, Dale AM. Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Trans Med Imaging 2001; 20: 70-80.
  13. Bar M, Tootell RB, Schacter DL, Greve DN, Fischl B, Mendola JD, Rosen BR, Dale AM. Cortical mechanisms specific to explicit visual object recognition. Neuron 2001; 29: 529-535.
  14. Sasaki Y, Hadjikhani N, Fischl B, Liu AK, Marrett S, Dale AM, Tootell RB. Local and global attention are mapped retinotopically in human occipital cortex. Proc Natl Acad Sci U S A 2001; 98: 2077-2082.
  15. Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 2001; 98: 4687-4692.
  16. Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B. Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology 2002; 58: 695-701.
  17. Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002; 33: 341-355.
  18. Golland P, Fischl B, Spiridon M, Kanwisher N, Buckner RL, Shenton ME, Kikinis R, Dale AM, Grimson EL. Discriminative analysis for image-based studies. In: Fifth International Conference on Medical Image Computing and Computer Assisted Intervention; 2002.
  19. Sailer M, Fischl B, Salat D, Tempelmann C, Schonfeld MA, Busa E, Bodammer N, Heinze HJ, Dale A. Focal thinning of the cerebral cortex in multiple sclerosis. Brain 2003; 126: 1734-1744.
  20. Makris N, Hodge SM, Haselgrove C, Kennedy DN, Dale A, Fischl B, Rosen BR, Harris G, Caviness VS, Jr., Schmahmann JD. Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging. J Cogn Neurosci 2003; 15: 584-599.
  21. Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, Ozawa F, Goff D, West WC, Williams SC, van der Kouwe AJ, Salat DH, Dale AM, Fischl B. Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry 2003; 60: 878-888.
  22. Fischl B, van der Kouwe A, Destrieux C, Halgren E, Segonne F, Salat DH, Busa E, Seidman LJ, Goldstein J, Kennedy D, Caviness V, Makris N, Rosen B, Dale AM. Automatically parcellating the human cerebral cortex. Cereb Cortex 2004; 14: 11-22.
  23. Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, Morris JC, Dale AM, Fischl B. Thinning of the cerebral cortex in aging. Cereb Cortex 2004; 14: 721-730.
  24. Fjell AM, Walhovd KB, Reinvang I, Lundervold A, Dale AM, Quinn BT, Makris N, Fischl B. Age does not increase rate of forgetting over weeks-Neuroanatomical volumes and visual memory across the adult life-span. J Int Neuropsychol Soc 2005; 11: 2-15.
  25. Walhovd KB, Fjell AM, Reinvang I, Lundervold A, Fischl B, Salat D, Quinn BT, Makris N, Dale AM. Cortical volume and speed-of-processing are complementary in prediction of performance intelligence. Neuropsychologia 2005; 43: 704-713.
  26. Koo D, Maisog J, Fischl B, La Sasso C, DeWitt I, Lansdale M, Crain K, Eden G. Cortical thickness in deaf and hearing adults. In Preparation.
  27. Rauch S, Wright C, Martis B, Busa E, McMullin K, Shin L, Dale A, Fischl B. A magnetic resonance imaging study of cortical thickness in animal phobia. Biol Psychiatry In Press.
  28. Segonne F, Dale A, Busa E, Glessner M, Salvolini U, Hahn H, Fischl B. A hybrid approach to the skull-stripping problem in MRI. NeuroImage In Press.
  29. Walhovd K, Fjell A, Reinvang I, Lundervold A, Fischl B, Quinn B, Dale A. Size does matter in the long run hippocampal and cortical volume predict recall across weeks. Neurology In Press.
  30. Fischl B, Salat D, van der Kouwe A, Makris N, Ségonne F, Dale A. Sequence-independent segmentation of magnetic resonance images. NeuroImage In Press.
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