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Guinevere Eden, D. Phil.

Associate Professor, Department of Pediatrics and Director, Center for the Study of Learning

B.Sc. -- University College London, 1989, Physiology.
D. Phil. -- Oxford University, 1993, Physiology

Guinevere Eden received her D.Phil. in Physiology from Oxford University and has since focused on the application of functional neuroimaging techniques to study the neural basis of developmental dyslexia. The Center for the Study of Learning is funded under the P50 mechanism by the National Institutes of Child Health and Human Development, National Institutes of Health. In collaboration with Gallaudet University and Wake Forest School of Medicine, the CSL's research focuses on the neural representation of reading and how it may be altered in individuals with developmental disorders or altered early sensory experience. Further, she and her colleagues are researching how reading is impacted by instructions or mode of communication and are utilizing functional MRI to study the neurobiological correlates of reading remediation.

Dr. Eden also serves as a scientific co-director for the Science of Learning Center on Visual Language and Visual Learning (VL2) at Gallaudet University. The purpose of VL2 is to gain a greater understanding of the biological, cognitive, linguistic, socio-cultural, and pedagogical conditions that influence the acquisition of language and knowledge through the visual modality.

Dr. Eden teaches students enrolled in the graduate neuroscience program She is currently president of the International Dyslexia Association and serves on the editorial boards of the Annals of Dyslexia, Dyslexia, and Human Brain Mapping. She has served as a permanent member of a standing NIH Study Section and as ad-hoc member and chair for special emphasis panels.

Book Chapters and Invited Articles

  1. Eden, G. F., J. F. Stein and F. B. Wood (1993). Visuospatial ability and language processing in reading disabled and normal children. Studies in Visual Information Processing: Facets of dyslexia and its remediation. S. F. Wright and R. Groner. North-Holland, Elsevier: 321-335.
  2. Eden, G.F., J. W. VanMeter, J. M. Rumsey and T.A. Zeffiro, (1996). Looking beyond the reading problems in developmental dyslexia: visualising the visual processing deficits. NIH Research, 8, 31-35. Eden, G.F. (1996).
  3. Eden, G. F. and T. A. Zeffiro (1996). Sensitivity of PET and fMRI in the detection of task related brain activity: implications for the study of brain development. In G. R. Lyon, J. Rumsey, N. Krasnegor, and R. W. Thatcher (Eds.). Developmental Neuroimaging: Mapping the Development of Brain and Behavior. San Diego, Academic Press, Inc: 77-87.
  4. Hilton, M., T. Ogden, D. Hattery, G. Eden and B. Jawerth (1996). Wavelet denoising of functional MRI data. Wavelets in Biology and Medicine. A. Aldroubi and M. Unser, CRC Press: 93-112.
  5. Rumsey, J. M. and G. F. Eden (1998). Functional neuroimaging of developmental dyslexia: Regional cerebral blood flow in dyslexic men. Specific Reading Disability: A View of the Spectrum. B. Shapiro, P. J. Accardo basis for reading. Journal of Learning Disabilities 34(6): 566-579.
  6. Eden, G. F. and T. A. Zeffiro (1998). Looking beyond the reading difficulties in dyslexia, a vision deficit. Biopsychology 98/99. B. M. Jubilan. Guilford, Dushkin/McGraw-Hill: 192-196.
  7. Eden, G. F., Zeffiro, T.A. (1999). Functional neuroimaging in developmental dyslexia. In P. Bandettini, C. Moone (eds.), Medical Radiology: Diagnostic Imaging and Radiation Oncology. Berlin: Springer-Verlag.
  8. Eden, G. F. and T. A. Zeffiro (1999). Techniques for Functional Neuroimaging: Functional magnetic resonance imaging (fMRI). In J.M. Rumsey and M. Ernst (Eds.). The Foundation and Future of Functional Neuroimaging in Child Psychiatry, Cambridge University Press.
  9. Turkeltaub, P.E., Weisberg, J., Flowers, D.L. Basu, D and Eden, G.F. (2005) The Neurobiological Basis of Reading: A Special Case of Skill Acquisition. In: Catts, H., & Kahmi, A. (Eds.) The connections between language and reading disabilities, pp103-130. Mahway, NJ: Erlbaum.
  10. Eden, G.F. and Flowers, D.L (2008) Developmental Dyslexia, In: C. A. Nelson and M. Luciana Handbook of Developmental Cognitive Neuroscience, MIT Press.
  11. Eden, G.F. and Flowers, D.L (2008) Developmental Dyslexia, In L. S. Squire, T. Albright, F. Bloom, F. Gage, and N. Spitzer, New Encyclopedia of Neuroscience, Elsevier, Oxford UK.

Reviews and Comments

  1. Eden, G.F., Zeffiro, T.A. (1998). Neural systems affected in developmental dyslexia revealed by functional neuroimaging. Neuron, 21, 279-282.
  2. Zeffiro, T.A., Eden, G.F. (2000). What's the matter? White matter? Neuron, 25(2), 257-9.
  3. Zeffiro, T. and G. Eden (2001). The cerebellum and dyslexia: perpetrator or innocent bystander? Trends in Neurosciences 24(9): 512-3.
  4. Eden, G. F. and L. Moats (2002). The role of neuroscience in the remediation of students with dyslexia. Nature Neuroscience 5 Suppl: 1080-4.
  5. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1995). Verbal and visual problems in reading disabled and normal children. Journal of Learning Disabilities, 28(5), 272-290.
  6. Eden, G. F. (1996). Verbal and Visual problems in reading disabled and normal children - a response to Dr. Cherkes-Julkowski. Journal of Learning Disabilities 29(1): 8.
  7. Eden, G. F. and T. A. Zeffiro (2000). The possible relationship between visual deficits and dyslexia: Examination of a critical assumption - Comments on Skottun and Parke. Journal of Learning Disabilities 32(5): 378.

Journal Articles

  1. Eden, G. F., J. F. Stein, M. H. Wood and F. B. Wood (1993). Dyslexia: a study of preserved and impaired visuospatial and phonological functions. Annals of the New York Academy of Sciences 682: 335-8.
  2. Eden, G. F., J. F. Stein, H. M. Wood and F. B. Wood (1994). Differences in eye movements and reading problems in dyslexic and normal children. Vision Research 34(10): 1345-58.
  3. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1995). Temporal and spatial processing in reading disabled and normal children. Cortex, 31, 451-468.
  4. Hilton, M., T. Ogden, D. Hattery, G. Eden and B. Jawerth (1996). Wavelet denoising of functional MRI data. Wavelets in Biology and Medicine. A. Aldroubi and M. Unser, CRC Press: 93-112.
  5. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1996). Visuospatial judgment in reading disabled and normal children. Perceptual and Motor Skills, 82, 155-177.
  6. Eden, G.F., VanMeter, J.W., Rumsey, J.W., Maisog, J. and T.A. Zeffiro, (1996). Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature, 348, 66-69.
  7. Eden, G.F., Zeffiro, T.A. (1996). The visual deficit theory of developmental dyslexia. NeuroImage, 4(3), S108-S117.
  8. Zeffiro, T.A., Eden, G.F., Woods, R.P., VanMeter, J.W. (1997). Intersubject analysis of fMRI data using spatial normalization. Advances in Experimental Medicine and Biology, 413, 235-240.
  9. Eden, G.F., Joseph, J.E., Brown, H.E., Brown, C.P., Zeffiro, T.A. (1999). Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: the Behavioral Interleaved Gradients Technique. Magnetic Resonance in Medicine, 41(1), 13-20.
  10. Zeffiro, T. and G. Eden (2000). The neural basis of developmental dyslexia. Annals of Dyslexia 50: 3-30.
  11. Joseph, J. E., K. Noble and G. F. Eden (2001). The neurobiological basis for reading. Journal of Learning Disabilities 34(6): 566-579.
  12. Turkeltaub, P. E., G. F. Eden, K. M. Jones and T. A. Zeffiro (2002). Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage 16(3 Pt 1): 765-80.
  13. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (2003). Clock drawing in reading disabled children. Journal of Learning Disabilities, 36,3, 216-228.
  14. Turkeltaub, P. E., Gareau, L., Flowers, D. L., Zeffiro, T. A., Eden, G. F. (2003). Development of neural mechanisms for reading. Nature Neuroscience, 6(7):767-73.
  15. Agnew, J., Dorn, D., Eden, G.F. (2004). Effect of intensive training on rapid temporal processing. Brain and Language, 88 (1), 21-25.
  16. Lin, F-H, A.R. McIntosh; J. Agnew, G.F. Eden, T.A. Zeffiro and J.W. Belliveau (2003). Multivariate analysis of neuronal interactions in the generalized partial least squares framework: Simulations and empirical studies. Neuroimage, 20(2):625-42
  17. Flowers D.L., Jones K., Noble K., VanMeter J.W., Zeffiro T.A., Wood F.B., Eden G.F. (2004). Attention to single letters activates left extrastriate cortex. NeuroImage, 21(3), 829-839.
  18. Turkeltaub, P.E., D. L. Flowers, A. Verbalis, M. Miranda, L.Gareau and G.F. Eden (2004). The neural basis of hyperlexic reading: an fMRI case study. Neuron, 41, pp 1-20
  19. J.A. Agnew, T.A. Zeffiro and G.F. Eden (2004). Left hemisphere specialization for the control of variable rate voluntary movement. NeuroImage, 22, (1) 289-303.
  20. Eden, G. F., Jones, K.M., Cappell, K., Gareau, L., Wood, F.B., Zeffiro, T.A., Dietz, N.A.E., Agnew, J.A. and Flowers, D.L. (2004). Neural changes following remediation in adult developmental dyslexia, Neuron, 44 (3), 411-422.
  21. Dietz, N.A.E., Jones, K. M., Gareau, L., Zeffiro, T. A., and Eden, G.F. (2005). The role of the left posterior fusiform cortex in phonological decoding. Human Brain Mapping, 26(2):81-93.
  22. Tan, L.H., Spinks, J.A., Eden, G.F., Perfetti, C.C., and Siok, W.T. (2005). Reading depends on writing in Chinese. Proceedings of the National Academy of Sciences, (24) 8781-8785
  23. Howard JH, Howard D, Japikse KA, Eden GF (2006). Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning. Neuropsychologia, 44 (7), 1131-44.
  24. Chait M, Eden GF, Poeppel D, Simon JZ, Hill DF and Flowers DL (2006). Delayed detection of tonal targets in background noise in dyslexia. Brain and Language, PMID: 16887180.
  25. Leonard CM, Eckert MA, Given BK, Berninger VW and Eden GF (2006). Individual differences in anatomy predict reading and oral language deficits. Brain.
  26. Given BK, Wasserman JD, Chari SA, Beattie K, Eden GF. A randomized, controlled study of computer-based intervention in middle school struggling readers. Brain Lang. 2008 Aug;106(2):83-97.
  27. Maisog, J.M., Einbinder, E.R., Turkeltaub, P.E., Flowers, D.L., and Eden, G.F. (2008). A meta-analysis of reading in developmental dyslexia. Annals of the New York Academy of Sciences, 1145:237-59.
  28. Eden, G.F. and Vaidya, C. (2008). ADHD and dyslexia: neural basis and treatment. Annals of the New York Academy of Sciences, 1145:316-27.
  29. Turkeltaub, T.E., Flowers, D.L., Lyon, L.G. and Eden, G.F. (2008). Development of Ventral Stream Representations for Single Letters. Annals of the New York Academy of Sciences, 1145:13-29.
  30. Koo, D., Crain, K., LaSasso, C. and Eden G.F. (2008) Phonological Awareness and Short Term Memory in Hearing and Deaf Individuals of Different Communication Backgrounds. Annals of the New York Academy of Sciences, 1145:83-99.

Presentations:

Interviews:

  1. Brain Imaging - What does it tell us about reading?

IDA Conference 2008
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