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Guinevere Eden, D. Phil.

Professor, Department of Pediatrics and Director, Center for the Study of Learning

B.Sc. -- University College London, 1989, Physiology.
D. Phil. -- Oxford University, 1993, Physiology

Guinevere Eden received her D.Phil. in Physiology from Oxford University and has since focused on the application of functional neuroimaging techniques to study the neural basis of developmental dyslexia. The Center for the Study of Learning is funded by the National Institutes of Child Health and Human Development, National Institutes of Health. In collaboration with the Science of Learning Center on Visual Language and Visual Learning (VL2) at Gallaudet University and with Wake Forest School of Medicine, the CSL's research focuses on the neural representation of reading and how it may be altered in individuals with developmental disorders or altered early sensory experience. Further, she and her colleagues are researching how reading is impacted by instructions or mode of communication and are utilizing functional MRI to study the neurobiological correlates of reading remediation.

Dr. Eden teaches students enrolled in the graduate neuroscience program. She is past-president of the International Dyslexia Association and serves on the editorial boards of the Annals of Dyslexia, Dyslexia, Brain and Language, Developmental Cognitive Neuroscience and Human Brain Mapping. She has served as a permanent member of a standing NIH Study Section and as ad-hoc member and chair for special emphasis panels.

Book Chapters and Invited Articles

  1. Eden, G. F., J. F. Stein and F. B. Wood (1993). Visuospatial ability and language processing in reading disabled and normal children. Studies in Visual Information Processing: Facets of dyslexia and its remediation. S. F. Wright and R. Groner. North-Holland, Elsevier: 321-335.
  2. Eden, G.F., J. W. VanMeter, J. M. Rumsey and T.A. Zeffiro, (1996). Looking beyond the reading problems in developmental dyslexia: visualising the visual processing deficits. NIH Research, 8, 31-35. Eden, G.F. (1996).
  3. Eden, G. F. and T. A. Zeffiro (1996). Sensitivity of PET and fMRI in the detection of task related brain activity: implications for the study of brain development. In G. R. Lyon, J. Rumsey, N. Krasnegor, and R. W. Thatcher (Eds.). Developmental Neuroimaging: Mapping the Development of Brain and Behavior. San Diego, Academic Press, Inc: 77-87.
  4. Hilton, M., T. Ogden, D. Hattery, G. Eden and B. Jawerth (1996). Wavelet denoising of functional MRI data. Wavelets in Biology and Medicine. A. Aldroubi and M. Unser, CRC Press: 93-112.
  5. Rumsey, J. M. and G. F. Eden (1998). Functional neuroimaging of developmental dyslexia: Regional cerebral blood flow in dyslexic men. Specific Reading Disability: A View of the Spectrum. B. Shapiro, P. J. Accardo basis for reading. Journal of Learning Disabilities 34(6): 566-579.
  6. Eden, G. F. and T. A. Zeffiro (1998). Looking beyond the reading difficulties in dyslexia, a vision deficit. Biopsychology 98/99. B. M. Jubilan. Guilford, Dushkin/McGraw-Hill: 192-196.
  7. Eden, G. F., Zeffiro, T.A. (1999). Functional neuroimaging in developmental dyslexia. In P. Bandettini, C. Moone (eds.), Medical Radiology: Diagnostic Imaging and Radiation Oncology. Berlin: Springer-Verlag.
  8. Eden, G. F. and T. A. Zeffiro (1999). Techniques for Functional Neuroimaging: Functional magnetic resonance imaging (fMRI). In J.M. Rumsey and M. Ernst (Eds.). The Foundation and Future of Functional Neuroimaging in Child Psychiatry, Cambridge University Press.
  9. Turkeltaub, P.E., Weisberg, J., Flowers, D.L. Basu, D and Eden, G.F. (2005) The Neurobiological Basis of Reading: A Special Case of Skill Acquisition. In: Catts, H., & Kahmi, A. (Eds.) The connections between language and reading disabilities, pp103-130. Mahway, NJ: Erlbaum.
  10. Eden, G.F. and Flowers, D.L (2008) Developmental Dyslexia, In: C. A. Nelson and M. Luciana Handbook of Developmental Cognitive Neuroscience, MIT Press.
  11. Eden, G.F. and Flowers, D.L (2008) Developmental Dyslexia, In L. S. Squire, T. Albright, F. Bloom, F. Gage, and N. Spitzer, New Encyclopedia of Neuroscience, Elsevier, Oxford UK.

Reviews and Comments

  1. Eden, G.F., Zeffiro, T.A. (1998). Neural systems affected in developmental dyslexia revealed by functional neuroimaging. Neuron, 21, 279-282.
  2. Zeffiro, T.A., Eden, G.F. (2000). What's the matter? White matter? Neuron, 25(2), 257-9.
  3. Zeffiro, T. and G. Eden (2001). The cerebellum and dyslexia: perpetrator or innocent bystander? Trends in Neurosciences 24(9): 512-3.
  4. Eden, G. F. and L. Moats (2002). The role of neuroscience in the remediation of students with dyslexia. Nature Neuroscience 5 Suppl: 1080-4.
  5. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1995). Verbal and visual problems in reading disabled and normal children. Journal of Learning Disabilities, 28(5), 272-290.
  6. Eden, G. F. (1996). Verbal and Visual problems in reading disabled and normal children - a response to Dr. Cherkes-Julkowski. Journal of Learning Disabilities 29(1): 8.
  7. Eden, G. F. and T. A. Zeffiro (2000). The possible relationship between visual deficits and dyslexia: Examination of a critical assumption - Comments on Skottun and Parke. Journal of Learning Disabilities 32(5): 378.

Journal Articles

  1. Eden, G. F., J. F. Stein, M. H. Wood and F. B. Wood (1993). Dyslexia: a study of preserved and impaired visuospatial and phonological functions. Annals of the New York Academy of Sciences 682: 335-8.
  2. Eden, G. F., J. F. Stein, H. M. Wood and F. B. Wood (1994). Differences in eye movements and reading problems in dyslexic and normal children. Vision Research 34(10): 1345-58.
  3. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1995). Temporal and spatial processing in reading disabled and normal children. Cortex, 31, 451-468.
  4. Hilton, M., T. Ogden, D. Hattery, G. Eden and B. Jawerth (1996). Wavelet denoising of functional MRI data. Wavelets in Biology and Medicine. A. Aldroubi and M. Unser, CRC Press: 93-112.
  5. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1996). Visuospatial judgment in reading disabled and normal children. Perceptual and Motor Skills, 82, 155-177.
  6. Eden, G.F., VanMeter, J.W., Rumsey, J.W., Maisog, J. and T.A. Zeffiro, (1996). Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature, 348, 66-69.
  7. Eden, G.F., Zeffiro, T.A. (1996). The visual deficit theory of developmental dyslexia. NeuroImage, 4(3), S108-S117.
  8. Zeffiro, T.A., Eden, G.F., Woods, R.P., VanMeter, J.W. (1997). Intersubject analysis of fMRI data using spatial normalization. Advances in Experimental Medicine and Biology, 413, 235-240.
  9. Eden, G.F., Joseph, J.E., Brown, H.E., Brown, C.P., Zeffiro, T.A. (1999). Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: the Behavioral Interleaved Gradients Technique. Magnetic Resonance in Medicine, 41(1), 13-20.
  10. Zeffiro, T. and G. Eden (2000). The neural basis of developmental dyslexia. Annals of Dyslexia 50: 3-30.
  11. Joseph, J. E., K. Noble and G. F. Eden (2001). The neurobiological basis for reading. Journal of Learning Disabilities 34(6): 566-579.
  12. Turkeltaub, P. E., G. F. Eden, K. M. Jones and T. A. Zeffiro (2002). Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage 16(3 Pt 1): 765-80.
  13. Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (2003). Clock drawing in reading disabled children. Journal of Learning Disabilities, 36,3, 216-228.
  14. Turkeltaub, P. E., Gareau, L., Flowers, D. L., Zeffiro, T. A., Eden, G. F. (2003). Development of neural mechanisms for reading. Nature Neuroscience, 6(7):767-73.
  15. Agnew, J., Dorn, D., Eden, G.F. (2004). Effect of intensive training on rapid temporal processing. Brain and Language, 88 (1), 21-25.
  16. Lin, F-H, A.R. McIntosh; J. Agnew, G.F. Eden, T.A. Zeffiro and J.W. Belliveau (2003). Multivariate analysis of neuronal interactions in the generalized partial least squares framework: Simulations and empirical studies. Neuroimage, 20(2):625-42
  17. Flowers D.L., Jones K., Noble K., VanMeter J.W., Zeffiro T.A., Wood F.B., Eden G.F. (2004). Attention to single letters activates left extrastriate cortex. NeuroImage, 21(3), 829-839.
  18. Turkeltaub, P.E., D. L. Flowers, A. Verbalis, M. Miranda, L.Gareau and G.F. Eden (2004). The neural basis of hyperlexic reading: an fMRI case study. Neuron, 41, pp 1-20
  19. J.A. Agnew, T.A. Zeffiro and G.F. Eden (2004). Left hemisphere specialization for the control of variable rate voluntary movement. NeuroImage, 22, (1) 289-303.
  20. Eden, G. F., Jones, K.M., Cappell, K., Gareau, L., Wood, F.B., Zeffiro, T.A., Dietz, N.A.E., Agnew, J.A. and Flowers, D.L. (2004). Neural changes following remediation in adult developmental dyslexia, Neuron, 44 (3), 411-422.
  21. Dietz, N.A.E., Jones, K. M., Gareau, L., Zeffiro, T. A., and Eden, G.F. (2005). The role of the left posterior fusiform cortex in phonological decoding. Human Brain Mapping, 26(2):81-93.
  22. Tan, L.H., Spinks, J.A., Eden, G.F., Perfetti, C.C., and Siok, W.T. (2005). Reading depends on writing in Chinese. Proceedings of the National Academy of Sciences, (24) 8781-8785
  23. Howard JH, Howard D, Japikse KA, Eden GF (2006). Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning. Neuropsychologia, 44 (7), 1131-44.
  24. Chait M, Eden GF, Poeppel D, Simon JZ, Hill DF and Flowers DL (2006). Delayed detection of tonal targets in background noise in dyslexia. Brain and Language, PMID: 16887180.
  25. Leonard CM, Eckert MA, Given BK, Berninger VW and Eden GF (2006). Individual differences in anatomy predict reading and oral language impairments in children. Brain. 129.12(2006):3329-42.
  26. Given BK, Wasserman JD, Chari SA, Beattie K, Eden GF. A randomized, controlled study of computer-based intervention in middle school struggling readers. Brain Lang. 2008 Aug;106(2):83-97.
  27. Maisog, J.M., Einbinder, E.R., Turkeltaub, P.E., Flowers, D.L., and Eden, G.F. (2008). A meta-analysis of reading in developmental dyslexia. Annals of the New York Academy of Sciences, 1145:237-59.
  28. Eden, G.F. and Vaidya, C. (2008). ADHD and developmental dyslexia: two pathways leading to impaired learning. Annals of the New York Academy of Sciences, 1145:316-27.
  29. Turkeltaub, T.E., Flowers, D.L., Lyon, L.G. and Eden, G.F. (2008). Development of Ventral Stream Representations for Single Letters. Annals of the New York Academy of Sciences, 1145:13-29.
  30. Koo, D., Crain, K., LaSasso, C. and Eden G.F. (2008) Phonological Awareness and Short Term Memory in Hearing and Deaf Individuals of Different Communication Backgrounds. Annals of the New York Academy of Sciences, 1145:83-99.
  31. Krafnick, A.J., Flowers, D.L., Napoliello, E.M., Eden, G.F. (2011). Gray matter volume changes following reading intervention in dyslexic children. Neuroimage, 1;57(3):733-41.
  32. Purcell, J.J., Napoliello, E.M., Eden, G.F. (2011). A Combined fMRI Study of Typed Spelling and Reading. NeuroImage, 15;55(2):750-62.
  33. Jamal, N.I., Piche, A.W., Napoliello, E.M., Perfetti, C.A., Eden, G.F. (2012). Neural basis of single-word reading in Spanish-English bilinguals. Human Brain Mapping, 33(1):235-45.
  34. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S. (2011) Harnessing neuroplasticity for clinical applications, Brain, 134(Pt 6):1591-609.
  35. Purcell, J.J., Turkeltaub, P.E., Eden, G.F., Rapp, R. (2011). Examining the central and peripheral processes of written word production through meta-analysis. Frontiers in Language Sciences 2:239.
  36. Weisberg, J., Koo, D.S., Crain, K.L., Eden, G.F. (2012). Cortical plasticity for visuospatial processing and object recognition in deaf and hearing signers. Neuroimage. 60(1):661-72.
  37. Olulade, O.A., Flowers, D.L., Napolielo, E.M., Eden, G.F. (2013). Developmental differences for word processing in the ventral stream. Brain and Language. 125(2):134-45.
  38. Olulade, O.A., Napolielo, E.M., Eden, G.F. (2013). Abnormal Visual Motion Processing is not a Cause of Dyslexia. Neuron. 79(1):180-90.
  39. Evans TM, Flowers DL, Napoliello EM, Eden GF. (2014). Sex-specific gray matter volume differences in females with developmental dyslexia. Brain Struct Funct. 219(3): 1041-54.
  40. Krafnick, A.J., Flowers, D.L., Luetje, M.M., Napoliello, E.M., Eden, G.F. (2014). An investigation into the origin of anatomical differences in dyslexia. Journal of Neuroscience. 34(3):901-8.
  41. Olulade, O.A., Koo, D.S., LaSasso, C.J., Eden, G.F. (2014). Neuroanatomical profiles of deafness in the context of native language experience. Journal of Neuroscience. 34(16):5613-20.
  42. Evans, T.M., Flowers, D.L., Napoliello, E.M., Olulade, O.A., Eden, G.F. (2014). The functional anatomy of single-digit arithmetic in children with developmental dyslexia. Neuroimage. Jul 25 [Epub ahead of print]
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